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| Caption | Determination of ICAM-1 in aortic roots of atheroprone mice with (Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw) and without (Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw) endothelial-specific deletion of NCK2. Animals were fed a HFD for 8 or 16 weeks to assess atherosclerotic lesion initiation and progression, respectively. (A/C) Representative confocal images of aortic roots showing immunofluorescence staining of endothelial (CD31) and cell adhesion (ICAM-1) markers in males (A) and females (C). The dotted yellow, white, and green lines contour the aortic root section, intimal, and neointima layers, respectively. The scale bars represent 50 um unless otherwise indicated. (B/D) Box plots showing quantification of total (left panels), intimal (center panels), and neointimal (right panels) ICAM-1 in males (B) and females (D). Total ICAM-1was calculated as ICAM-1 area in entire root/root area. Intimal ICAM-1 was calculated as the area of ICAM-1/area of CD31 in signal in a 10 um-thick periluminal layer (intima). Neointimal ICAM-1 was calculated as area of ICAM-1/neointimal area. Dots represent individual animals and the number of animals per group is indicated in parentheses. Statistical significance was determined by Wilcoxon Rank Sum Test with Bonferroni correction. *p < 0.05. | ||||||||||
| Copyright | This image is from the Laboratory of Dr. Gonzalo M Rivera at Texas A&M University and is displayed with the permission of the author. J:327349 | ||||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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