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| Caption | The retinal degeneration 26 (rd26) heritable mutant phenotype was discovered in an ocular phenotypes screening program in April 2015 in a male mouse of strain STOCK Terctm1Rdp Dmdmdx/J (JAX Stock No. 018915) that presented with late-onset progressive retinal degeneration at 4 months of age (B and E), but the female mouse from that strain was normal at 4 month of age (A). We mated the mutant male mouse with C57BL/6J and all F1 mice had normal retinas. Then we mated the mutant male mouse again to the F1 female mice and the retinal degeneration phenotype was recovered in half of the backcross generation. We developed a C57BL/6J (B6) congenic strain, B6.Cg-rd26/Boc (JAX Stock No. 036973), by backcross-intercross breeding the rd26 allele onto C57BL/6J for 5 cycles to generation NE5 then sibling mating to homozygosity. Mice homozygous for rd26 begin to show retinal degeneration at about 4 months of age (B and E) in OCT and histology and show attenuated vessels and retinal degeneration at 6 months of age (C). By 10 months of age homozygotes showed ~90% photoreceptor loss (D and F). The green lines are the plane in which the B-scan to the left of the fundus images were taken in the same animal. | ||||
| Copyright | Photo courtesy of Mouse Mutant Resource at The Jackson Laboratory. J:350383 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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