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Phenotype Image Detail
Image
Caption Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp mutants are recovered at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates limited expression during development. Knock-in LacZ showed no staining during gastrulation stages (E6.5, E7.5, E8.5). Additional information at websites.umass.edu/jmager/Ap2s1
Copyright This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207
Associated
Alleles
Symbol Name
Ap2s1em1(IMPC)Tcp adaptor-related protein complex 2, sigma 1 subunit; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Associated
Genotypes
Allelic Composition Genetic Background
Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Cmmr

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory