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Phenotype Image Detail
Image
Caption Med20em1(IMPC)J/Med20em1(IMPC)J embryos cannot be recovered at E7.5 (0/28), nor are the excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as normal blastocysts. Mutants fail to hatch from the zona with apparent cell death and failure to form a typical outgrowth colony (no trophectoderm/primitive endoderm/epiblast cells). RT-PCR indicates robust expression at most embryonic stages with notable absence in the blastocyst. Additional information at websites.umass.edu/jmager/Med20
Copyright This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207
Associated
Alleles
Symbol Name
Med20em1(IMPC)J mediator complex subunit 20; endonuclease-mediated mutation 1, Jackson
Associated
Genotypes
Allelic Composition Genetic Background
Med20em1(IMPC)J/Med20em1(IMPC)J C57BL/6NJ-Med20em1(IMPC)J/J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory