Phenotype Image Detail

Image

Caption

Timm22^{tm1b(KOMP)Wtsi}/Timm22^{tm1b(KOMP)Wtsi} mutants are recovered in expected ratios at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates robust expression in gastrulation stages. Strong knock-in LacZ reporter expression is observed at E7.5 and E8.5. Additional information at websites.umass.edu/jmager/Timm22

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated
Alleles

Symbol	Name
Timm22^{tm1b(KOMP)Wtsi}	translocase of inner mitochondrial membrane 22; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Timm22^{tm1b(KOMP)Wtsi}/Timm22^{tm1b(KOMP)Wtsi}	C57BL/6N-Timm22^{tm1b(KOMP)Wtsi}/JMmucd

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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