Phenotype Image Detail

Image

Caption

Mcrs1^{tm1.1(KOMP)Vlcg}/Mcrs1^{tm1.1(KOMP)Vlcg} embryos cannot be recovered at E7.5 (0/32), nor are the excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as normal blastocysts. Mutants hatch from the zona with apparent trophectoderm and primitive endoderm cells, but the inner cell mass/epiblast cells fail to form a typical outgrowth colony. RT-PCR indicates limited expression during pre-implantation but robust post-implantation expression. Very weak lacZ reporter post-implantation. Additional information at websites.umass.edu/jmager/Mcrs1

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated
Alleles

Symbol	Name
Mcrs1^{tm1.1(KOMP)Vlcg}	microspherule protein 1; targeted mutation 1.1, Velocigene

Associated
Genotypes

Allelic Composition	Genetic Background
Mcrs1^{tm1.1(KOMP)Vlcg}/Mcrs1^{tm1.1(KOMP)Vlcg}	B6N(Cg)-Mcrs1^{tm1.1(KOMP)Vlcg}/J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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