Phenotype Image Detail

Image

Caption

Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1^{tm1.1(KOMP)Vlcg} embryos cannot be recovered at E7.5 (0/30), nor are the excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as normal blastocysts. Mutants hatch from the zona and generate morphologically typical outgrowth colonies (trophectoderm/primitive endoderm/inner cell mass). RT-PCR indicates limited expression during pre-implantation but robust post-implantation expression. Robust LacZ knock-in reporter post-implantation. Additional information at websites.umass.edu/jmager/Dbr1

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated
Alleles

Symbol	Name
Dbr1^{tm1.1(KOMP)Vlcg}	debranching RNA lariats 1; targeted mutation 1.1, Velocigene

Associated
Genotypes

Allelic Composition	Genetic Background
Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1^{tm1.1(KOMP)Vlcg}	B6N(Cg)-Dbr1^{tm1.1(KOMP)Vlcg}/J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24