Phenotype Image Detail

Image

Caption

Mrps22^{tm1.1(KOMP)Vlcg}/Mrps22^{tm1.1(KOMP)Vlcg} are recovered at expected mendelian ratios at E7.5. Mutants show consistent phenotype including developmental delay (~E6.0 size), no morphological hallmarks of gastrulation and no Brachyury (T)-positive cells. Phospho-histoneH3 (PH3) shows many dividing cells despite the overall developmental delay. RT-PCR show largely ubiquitous expression. Knock-in lacZ reporter shows no staining during gastrulation stages (only E7.5 shown). Additional information at websites.umass.edu/jmager/Mrps22

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated
Alleles

Symbol	Name
Mrps22^{tm1.1(KOMP)Vlcg}	mitochondrial ribosomal protein S22; targeted mutation 1.1, Velocigene

Associated
Genotypes

Allelic Composition	Genetic Background
Mrps22^{tm1.1(KOMP)Vlcg}/Mrps22^{tm1.1(KOMP)Vlcg}	C57BL/6N-Mrps22^{tm1.1(KOMP)Vlcg}/JMmucd

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24