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Phenotype Image Detail
Image
Caption Prpf4bem1(IMPC)J/Prpf4bem1(IMPC)J embryos cannot be recovered at E7.5 (0/27), nor are there excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as early blastocysts/late morula. Mutants fail to hatch from the zona with apparent cell death, never reaching a morphological blastocyst stage or forming a normal outgrowth. RT-PCR indicates robust expression starting at the 16-cell stage and post-implantation. Additional information at websites.umass.edu/jmager/Prpf4b
Copyright This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207
Associated
Alleles
Symbol Name
Prpf4bem1(IMPC)J pre-mRNA processing factor 4B; endonuclease-mediated mutation 1, Jackson
Associated
Genotypes
Allelic Composition Genetic Background
Prpf4bem1(IMPC)J/Prpf4bem1(IMPC)J C57BL/6NJ-Prpf4bem1(IMPC)J/J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory