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Phenotype Image Detail
Image
Caption Polr1dem1(IMPC)J/Polr1dem1(IMPC)J embryos cannot be recovered at E7.5 (0/37), nor are there excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as compacted morula. Mutants fail to hatch from the zona with apparent cell death, never reaching a morphological blastocyst stage. RT-PCR indicates robust expression in the oocyte and post-implantation. Additional information at websites.umass.edu/jmager/Polr1d
Copyright This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207
Associated
Alleles
Symbol Name
Polr1dem1(IMPC)J polymerase (RNA) I polypeptide D; endonuclease-mediated mutation 1, Jackson
Associated
Genotypes
Allelic Composition Genetic Background
Polr1dem1(IMPC)J/Polr1dem1(IMPC)J C57BL/6NJ-Polr1dem1(IMPC)J/Mmjax

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory