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Phenotype Image Detail
Image
Caption Ttkem1(IMPC)J/Ttkem1(IMPC)J embryos cannot be recovered at E7.5 (0/26), however excess resorption sites suggest mutants elicit a decidual response in vivo. Homozygous mutants are recovered at E3.5 and appear as blastocysts. Mutants hatch from the zona and form outgrowths with apparent trophectoderm and primitive endoderm cells, but small inner cell mass. RNA-seq data indicates robust maternal and post-zygotic expression. Additional information at websites.umass.edu/jmager/Ttk
Copyright This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207
Associated
Alleles
Symbol Name
Ttkem1(IMPC)J Ttk protein kinase; endonuclease-mediated mutation 1, Jackson
Associated
Genotypes
Allelic Composition Genetic Background
Ttkem1(IMPC)J/Ttkem1(IMPC)J C57BL/6NJ-Ttkem1(IMPC)J/Mmjax

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory