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| Caption | Exosc1em1(IMPC)J/Exosc1em1(IMPC)J embryos can be recovered at E7.5, but they are smaller than their littermates and show many morphological defects, never initiating gastrulation. At E5.5, mutant embryos appear similar in size to control littermates with normal radially symmetrical egg cylinder morphology, albeit the mutant embryonic ectoderm seems slightly disorganized. TUNEL assay reveals TUNEL positive cells specifically in the epiblast of Exosc1 mutants. Exosc1 is ubiquitously expressed throughout embryo development. RT-PCR expression of the 10 murine Exosc genes in various tissues and development stages indicates widespread expression. Additional information at websites.umass.edu/jmager/exosc1 | ||||
| Copyright | This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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