Phenotype Images associated with this Allele

Nomenclature

Symbol:	Apoe^tm1Unc
Name:	apolipoprotein E; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857129
Synonyms:	AopE(-), apoE-, apoE0, ApoE-KO, APOE KO, Apoe^tm1Un, EKO, epsilon-, mE^-, mEKO

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Assessment of atherosclerosis initiation and progression in tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.	Apoe^tm1Unc/Apoe^tm1Unc Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
	Morphometric analysis of aortic root lesions in tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.	Apoe^tm1Unc/Apoe^tm1Unc Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
	Determination of ICAM-1 in aortic roots of tamoxifen treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.	Apoe^tm1Unc/Apoe^tm1Unc Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
	Reduced inflammation in aortic roots obtained from tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.	Apoe^tm1Unc/Apoe^tm1Unc Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
	Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc aortas develop more atherosclerotic lesions after a high fat diet challenge	Apoe^tm1Unc/Apoe^tm1Unc Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: 129P2/OlaHsd * FVB/N
	Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri mice develop occlusive, atherosclerotic coronary artery disease	Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
	Decreased aortic root atherosclerosis susceptibility in Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex mice	Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex	B6.129-Hsd11b1^tm1Lex Apoe^tm1Unc
	Lower levels of lipid droplets in Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex macrophages	Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex	B6.129-Hsd11b1^tm1Lex Apoe^tm1Unc
	Decreased susceptibility to atherosclerosis in Apoe^tm1Unc/Apoe^tm1Unc Dp(17Nfkbil1-Or2h1)1Cogr/0 mice	Apoe^tm1Unc/Apoe^tm1Unc Dp(17Nfkbil1-Or2h1)1Cogr/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
	Morphology of aortic lesions in Apoe^tm1Unc/Apoe^tm1Unc and Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far mice	Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
		Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
	Cutaneous xanthomatosis and alopecia in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice	Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
		Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S7/SvEvBrd * C57BL/6
	Histopathology of cutaneous lesions developed in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice fed high fat diets	Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
		Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S7/SvEvBrd * C57BL/6
	Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far mice display severe xanthomatosis	Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
	Neutral lipid-poor atherosclerotic lesions in Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far and Soat1^tm1Far/Soat1^tm1Far Ldlr^tm1Her/Ldlr^tm1Her mice	Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
		Ldlr^tm1Her/Ldlr^tm1Her Soat1^tm1Far/Soat1^tm1Far	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

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