Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Hexb^tm1Rlp
Name:	hexosaminidase B; targeted mutation 1, Richard L Proia
MGI ID:	MGI:1857438
Synonyms:	Hexb-, Sandhoff hexb^-

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Localized glycolipid storage and microgliosis in Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 mice	Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0	involves: 129S4/SvJae * C57BL/6 * CBA
	Doxycycline treatment of Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 and Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 mice induces storage of glycolipids	Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0	involves: 129S4/SvJae * C57BL/6 * CBA
		Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0	involves: 129S4/SvJae * C57BL/6 * CBA
	Doxycycline treatment of Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 and Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 mice induces neuroinflammation	Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0	involves: 129S4/SvJae * C57BL/6 * CBA
		Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0	involves: 129S4/SvJae * C57BL/6 * CBA
	Peripheral monocytes/macrophages are seen in the central nervous system of Hexb^tm1Rlp/Hexb^tm1Rlp mice	Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
	Hexb^tm1Rlp/Hexb^tm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice	Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
		Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
	Lessened macrophage/microglia associated pathology in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice compared to Hexb^tm1Rlp/Hexb^tm1Rlp mice	Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
		Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
	Neuronal apoptosis is reduced in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice compared to Hexb^tm1Rlp/Hexb^tm1Rlp mice	Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
		Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
	Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mice have a hunched posture and are disheveled compared to B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mice	B4galnt1^tm1Rlp/B4galnt1^tm1Rlp Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
	Spinal cord pathology comparison of Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp and Hexb^tm1Rlp/Hexb^tm1Rlp mice	Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * C57BL/6
		B4galnt1^tm1Rlp/B4galnt1^tm1Rlp Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
	Purkinje cell degeneration in Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mice	Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * C57BL/6
		B4galnt1^tm1Rlp/B4galnt1^tm1Rlp Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

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