About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Prnptm1Cwe
Name: prion protein; targeted mutation 1, Charles Weissmann
MGI ID: MGI:1888773
Synonyms: Prnp-, Prn-p0, Prnp0, Prnp0 Zurich I, Prnptm1ZH1, Prnptm1Zrch, Prnp trn1Zrch, PrnpZH1, PrP0, PrPC-KO, PrPC Zrch-1, Zrch 1 Prnp0, ZrchI Prnp-, Zrch Prnp0, Zurich line
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe mice develop a lethal neurologic disease with lesions in the brain and muscleTg(Prnp)a20Cwe/0Not Specified
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0		involves: 129S7/SvEvBrd * C57BL/6
Ataxia, with circling movements and dargging of feet, in Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe mice.Tg(Prnp)a20Cwe/0Not Specified
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0		involves: 129S7/SvEvBrd * C57BL/6
Severe demyelinating lesions in Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe micePrnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0		involves: 129S7/SvEvBrd * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory