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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ptentm1Hwu
Name: phosphatase and tensin homolog; targeted mutation 1, Hong Wu
MGI ID: MGI:2156086
Synonyms: Ptenex5lox, PTENF, Ptenfl, Ptenflox, Ptenflx, Ptenfx, Ptenlox, Ptenloxp
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice develop anal squamous cell carcinomaPtentm1Hwu/Ptentm1Hwu
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Tg(KRT14-cre/ERT)20Efu/0		involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N
Increase in mesenchymal cell proliferation in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ micePtentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+		B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu
Abnormal airway capillary coupling in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ micePtentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+		B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu
Defect in angioblast differentiation in Ptentm1Hwu/Ptentm1Hwu Kdrtm1Jrt/Kdr+ Twist2tm1.1(cre)Dor/Twist2+ miceKdrtm1Jrt/Kdr+
Ptentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+		B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu
Vascular defects in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ embryosPtentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+		B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu
Generalized lack of vascularization in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ micePtentm1Hwu/Ptentm1Hwu
Twist2tm1.1(cre)Dor/Twist2+		B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu
Ovary tumors in Pik3catm1.1Waph/Pik3catm1.1Waph Ptentm1Hwu/Ptentm1Hwu micePik3catm1.1Waph/Pik3ca+
Ptentm1Hwu/Ptentm1Hwu		involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6
Smaller body size of Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 (HM) mice at P20Ptentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Intestinal pseudoobstruction in Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 (HM) micePtentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Hyperplasia and hypertrophy of Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 enteric neuronal cellsPtentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Hyperplasia of enteric neuronal crest cells and enteric glial cells in Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 colonPtentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Hyperpigmentation in Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 micePtentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 mice display hyperplasia of the submucosa plexus of the enteric nervous systemPtentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 mice present hyperplasia of the enteric glial cellsPtentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0		B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru
Altered dopamine neurons in the ventral midbrain of Ptentm1Hwu/Ptentm1Hwu Slc6a3tm1.1(cre)Bkmn/Slc6a3+ micePtentm1Hwu/Ptentm1Hwu
Slc6a3tm1.1(cre)Bkmn/Slc6a3+		involves: 129S4/SvJae * C57BL/6
Ptentm1Hwu/Ptentm1Hwu Slc6a3tm1.1(cre)Bkmn/Slc6a3+ mice show neuroprotective effects when treated with 6OHDA injection into the striatumPtentm1Hwu/Ptentm1Hwu
Slc6a3tm1.1(cre)Bkmn/Slc6a3+		involves: 129S4/SvJae * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory