Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Ccl2^tm1Rol
Name:	C-C motif chemokine ligand 2; targeted mutation 1, Barrett J Rollins
MGI ID:	MGI:2175911
Synonyms:	CCL2^-, CCL2KO, (MCP)1-, MCP-1-, MCP-1KO, Scya2-

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Retinal lesion in Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt mice	Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
	Retinal pigment epithelium damage, photoreceptor degeneration and amacrine cell alteration in Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt mice	Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
	Increased Bruch membrane thickness, vacuolated changes in retinal pigment epithelium, photoreceptor inner segment damage and outer segment disorientation in Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt eyes	Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
	Retinal microglial activation in different ages of Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt mice	Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
	Ccl2^tm1Rol/Ccl2^tm1Rol mice with experimental autoimmune encephalomyelitis show fewer inflammatory infiltrates in the spinal cord	Ccl2^tm1Rol/Ccl2^tm1Rol	B6.129S4-Ccl2^tm1Rol

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