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Phenotype Images associated with this Allele
Nomenclature
Symbol: Smotm2Amc
Name: smoothened, frizzled class receptor; targeted mutation 2, Andrew P McMahon
MGI ID: MGI:2176256
Synonyms: Smoc, Smof, Smofl, Smoflox
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Intestinal mesenchymal proliferation and expansion are affected in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryosSmotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryosGt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+		involves: 129S7/SvEvBrd
Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+		involves: 129S6/SvEvTac * 129S7/SvEvBrd
Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
Smotm2Amc/Smotm2Amc		involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory