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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pkd1tm1Shh
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie
MGI ID: MGI:2183431
Synonyms: Pkd1-, Pkd1del2, Pkd1del2-6
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Pkd1tm1.1Pcha/Pkd1tm1Shh mice develop in utero/early-onset autosomal dominant polycystic kidney diseasePkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Pkd1tm1.1Pcha/Pkd1tm1Shh mice show early-onset and rapidly progressive cystic diseasePkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha and Pkd1tm1.1Pcha/Pkd1tm1Shh mice show a switch in tubular cyst origin (from proximal tubule to collecting duct) corresponding to agePkd1tm1.1Pcha/Pkd1tm1.1Pchainvolves: 129S1/Sv * C57BL/6
Pkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Primary cilia are elongated in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha and Pkd1tm1.1Pcha/Pkd1tm1Shh collecting ductsPkd1tm1.1Pcha/Pkd1tm1.1Pchainvolves: 129S1/Sv * C57BL/6
Pkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Cyst development during embryogenesis and the first postnatal month in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha and Pkd1tm1.1Pcha/Pkd1tm1Shh animalsPkd1tm1.1Pcha/Pkd1tm1.1Pchainvolves: 129S1/Sv * C57BL/6
Pkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Illustration of kidney cyst disease variation in Pkd1tm1.1Pcha/Pkd1tm1Shh micePkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Anosteopenia in Pkd1tm1.1Pcha/Pkd1tm1Shh mice characterized by a decrease in cortical and trabecular bone massPkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Pkd1tm1.1Pcha/Pkd1tm1Shh animals show early signs of left ventricular hypertrophyPkd1tm1Shh/Pkd1tm1.1Pchainvolves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory