About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Sh2b3tm1Paw
Name: SH2B adaptor protein 3; targeted mutation 1, Tony Pawson
MGI ID: MGI:2383957
Synonyms: Lnk-
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Sh2b3tm1Paw/Sh2b3tm1Paw mice develop a chronic myeloid leukemia-like myeloproliferative diseaseSh2b3tm1Paw/Sh2b3tm1Pawinvolves: 129S1/Sv * 129X1/SvJ
Periportal cuffing of liver sinusoids with infiltrating myeloid cells is present in Sh2b3tm1Paw/Sh2b3tm1Paw miceSh2b3tm1Paw/Sh2b3tm1Pawinvolves: 129S1/Sv * 129X1/SvJ
Primary splenomegaly and extramedullary hematopoiesis in Sh2b3tm1Paw/Sh2b3tm1Paw miceSh2b3tm1Paw/Sh2b3tm1Paweither: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory