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Phenotype Images associated with this Allele
Nomenclature
Symbol: Sh2b3tm1Paw
Name: SH2B adaptor protein 3; targeted mutation 1, Tony Pawson
MGI ID: MGI:2383957
Synonyms: Lnk-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Sh2b3tm1Paw/Sh2b3tm1Paw mice develop a chronic myeloid leukemia-like myeloproliferative diseaseSh2b3tm1Paw/Sh2b3tm1Pawinvolves: 129S1/Sv * 129X1/SvJ
Periportal cuffing of liver sinusoids with infiltrating myeloid cells is present in Sh2b3tm1Paw/Sh2b3tm1Paw miceSh2b3tm1Paw/Sh2b3tm1Pawinvolves: 129S1/Sv * 129X1/SvJ
Primary splenomegaly and extramedullary hematopoiesis in Sh2b3tm1Paw/Sh2b3tm1Paw miceSh2b3tm1Paw/Sh2b3tm1Paweither: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory