About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Notch1tm2Rko
Name: notch 1; targeted mutation 2, Raphael Kopan
MGI ID: MGI:3044585
Synonyms: fN1, N1f, NICD1fl, Notch1f, Notch1flox, Notch1tm1Shn
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Corneal plaques and increased angiogenesis in the ear of Notch1tm2Rko/Notch1tm3(cre)Rko miceNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Notch1tm2Rko/Notch1tm3(cre)Rko mice develop vascular tumorsNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Tumor progression in Notch1tm2Rko/Notch1tm3(cre)Rko miceNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Embryonic lethality in Notch1tm2Rko/Notch1tm4(cre)Rko embryos due to the failure of angiogenic remodelingNotch1tm2Rko/Notch1tm4(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Notch1tm2Rko/Notch1tm3(cre)Rko mice show reactive splenomegaly to the inflammation in the liverNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Liver abnormalities and inflammation in Notch1tm2Rko/Notch1tm3(cre)Rko miceNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Well-differentiated hemangiosarcoma in Notch1tm2Rko/Notch1tm3(cre)Rko liverNotch1tm2Rko/Notch1tm3(cre)Rkoinvolves: 129X1/SvJ * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory