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Phenotype Images associated with this Allele
Nomenclature
Symbol: Med1tm2Jkr
Name: mediator complex subunit 1; targeted mutation 2, Janardan K Reddy
MGI ID: MGI:3511276
Synonyms: Med1fl, PBPfl
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Enlarged, flaccid and flabby hearts in Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 mice by E25.Med1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0		involves: 129P2/OlaHsd * FVB/N
Heart sections of Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 heart reveal thinning of ventricular walls and dilation of chambers.Med1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0		involves: 129P2/OlaHsd * FVB/N
Cardiac fibrosis, increased cardiomyocyte apoptosis and mitochondrial damage in Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 mouse heartMed1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0		involves: 129P2/OlaHsd * FVB/N
The Med1tm2Jkr/Med1tm2Jkr A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ mouse heart is flaccid and flabby after tamoxifen induction.Med1tm2Jkr/Med1tm2Jkr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+		involves: 129P2/OlaHsd * FVB/N
Cardiac fibrosis in Med1tm2Jkr/Med1tm2Jkr A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ mouse heartMed1tm2Jkr/Med1tm2Jkr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+		involves: 129P2/OlaHsd * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory