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Phenotype Images associated with this Allele
Nomenclature
Symbol: Abca12tm1Lex
Name: ATP-binding cassette, sub-family A member 12; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528440
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Neonatal lethality and epidermal hyperkeratosis in Abca12tm1Lex/Abca12tm1Lex miceAbca12tm1Lex/Abca12tm1Lexinvolves: 129S/SvEvBrd * C57BL/6J
Abca12tm1Lex/Abca12tm1Lex mice fail to develop the epidermal permeability barrierAbca12tm1Lex/Abca12tm1Lexinvolves: 129S/SvEvBrd * C57BL/6J
Hyperkeratosis of the stratum corneum and disrupted interstitial lamellar lipid structure in Abca12tm1Lex/Abca12tm1Lex miceAbca12tm1Lex/Abca12tm1Lexinvolves: 129S/SvEvBrd * C57BL/6J
Abca12tm1Lex/Abca12tm1Lex P0 pups are able to inflate their lungs if maintained in a hydrating environmentAbca12tm1Lex/Abca12tm1Lexinvolves: 129S/SvEvBrd * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory