Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Gba1^tm2Karl
Name:	glucosylceramidase beta 1; targeted mutation 2, Stefan Karlsson
MGI ID:	MGI:3764510
Synonyms:	gba^lnl

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/? mice display a severe and rapidly progressive neurological disease	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N
	Gba1^tm2Karl/Gba1^tm2Karl (upper left) mice display a lethal skin phenotype whileGba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/? (lower) mice display paralysis	Gba1^tm2Karl/Gba1^tm2Karl	involves: 129S1/Sv * 129X1/SvJ
		Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N
	Gba1^tm1Karl/Gba1^tm1Karl Tg(Nes-cre)1Kln/? mice exhibit a more profound activation and proliferation of microglial cells than Gba^tm2Karl/Gba^tm2Karl Tg(KRT14-cre)8Brn/? mice	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N
		Gba1^tm1Karl/Gba1^tm1Karl Tg(Nes-cre)1Kln/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/? mice display Gaucher cells in the liver and spleen	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N
	Neuronal loss in Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/? mice	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N
	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/? mice display astrogliosis and abnormal microglia	Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N

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