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Phenotype Images associated with this Allele
Nomenclature
Symbol: Col7a1tm1Lbt
Name: collagen, type VII, alpha 1; targeted mutation 1, Leena Bruckner-Tuderman
MGI ID: MGI:3796248
Synonyms: Col7a1flneo, TgH(COL7A1flNeo)288LBT
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Col7a1tm1Lbt/Col7a1tm1Lbt mice develop blisters early after birthCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Reduced collagen VII deposition in Col7a1tm1Lbt/Col7a1tm1Lbt mice results in dermal-epidermal separationCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Col7a1tm1Lbt/Col7a1tm1Lbt mice exhibit growth retardation as a result of malnutritionCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Paw deformities in Col7a1tm1Lbt/Col7a1tm1Lbt mice resemble severe human recessive dystrophic epidermolysis bullosaCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Mitten deformities of the extremities in the Col7a1tm1Lbt/Col7a1tm1Lbt mouse are not primarily caused by bone abnormalitiesCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Dermal-epidermal separation, higher dermis cellularity and reduced elastic fibers in Col7a1tm1Lbt/Col7a1tm1Lbt skinCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory