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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(MtTGFA)Lmb
Name: transgene insertion, Glenn Merlino
MGI ID: MGI:3800163
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 (STP) miceSmad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+		involves: 129S1/Sv * 129X1/SvJ
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0		involves: 129S1/Sv * 129X1/SvJ * CD-1
Tg(MtTGFA)Lmb/0involves: CD-1
Increased number of PanIN lesions in the Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 (STP) mice compared to Tg(MtTGFA)Lmb/0 (MT-TGFalpha) miceSmad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0		involves: 129S1/Sv * 129X1/SvJ * CD-1
Tg(MtTGFA)Lmb/0involves: CD-1
Enhanced pancreatic epithelial expasnion in Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 mice compared to Tg(MtTGFA)Lmb/0 miceSmad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0		involves: 129S1/Sv * 129X1/SvJ * CD-1
Tg(MtTGFA)Lmb/0involves: CD-1
Aggravated pancreatic fibrosis in Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 mice compared to Tg(MtTGFA)Lmb/0 miceSmad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0		involves: 129S1/Sv * 129X1/SvJ * CD-1
Tg(MtTGFA)Lmb/0involves: CD-1
Elevated Mucin-6 expression indicates pancreatitis in Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 (STP) miceSmad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0		involves: 129S1/Sv * 129X1/SvJ * CD-1
Tg(MtTGFA)Lmb/0involves: CD-1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory