About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Pthlhtm2Ack
Name: parathyroid hormone-like peptide; targeted mutation 2, Andrew C Karaplis
MGI ID: MGI:3826465
Synonyms: PTHrP(1-84), PthrpKI
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Pthlhtm2Ack/Pthlhtm2Ack mice show growth retardation, premature aging, osteopenia, kyphosis, muscle atrophy, decrease in adipose tissue, swelling of the brain, and thin skinPthlhtm2Ack/Pthlhtm2Ackinvolves: 129S2/SvPas * C57BL/6
Skeletal growth retardation caused by impaired growth plate chondrocyte proliferation in Pthlhtm2Ack/Pthlhtm2Ack micePthlhtm2Ack/Pthlhtm2Ackinvolves: 129S2/SvPas * C57BL/6
Pthlhtm2Ack/Pthlhtm2Ack mice develop severe premature osteoporosis resulting from defects of osteoblastic bone formationPthlhtm2Ack/Pthlhtm2Ackinvolves: 129S2/SvPas * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory