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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pthlhtm2Ack
Name: parathyroid hormone-like peptide; targeted mutation 2, Andrew C Karaplis
MGI ID: MGI:3826465
Synonyms: PTHrP(1-84), PthrpKI
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Pthlhtm2Ack/Pthlhtm2Ack mice show growth retardation, premature aging, osteopenia, kyphosis, muscle atrophy, decrease in adipose tissue, swelling of the brain, and thin skinPthlhtm2Ack/Pthlhtm2Ackinvolves: 129S2/SvPas * C57BL/6
Skeletal growth retardation caused by impaired growth plate chondrocyte proliferation in Pthlhtm2Ack/Pthlhtm2Ack micePthlhtm2Ack/Pthlhtm2Ackinvolves: 129S2/SvPas * C57BL/6
Pthlhtm2Ack/Pthlhtm2Ack mice develop severe premature osteoporosis resulting from defects of osteoblastic bone formationPthlhtm2Ack/Pthlhtm2Ackinvolves: 129S2/SvPas * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory