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Phenotype Images associated with this Allele
Nomenclature
Symbol: Mapk6tm1Melo
Name: mitogen-activated protein kinase 6; targeted mutation 1, Sylvain Meloche
MGI ID: MGI:4365549
Synonyms: Erk-, Erk3-, Mapk6LacZNeo
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mapk6tm1Melo/Mapk6tm1Melo mice display cyanosis, carpoptosis, smaller body weight, and neonatal lethalityMapk6tm1Melo/Mapk6tm1Meloinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6
Impaired saccular development of the lung in Mapk6tm1Melo/Mapk6tm1Melo miceMapk6tm1Melo/Mapk6tm1Meloinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6
DEfective maturation of the distal lung epithelium in Mapk6tm1Melo/Mapk6tm1Melo miceMapk6tm1Melo/Mapk6tm1Meloinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6
Antenatal dexmethasone rescues the lung maturation defect in Mapk6tm1Melo/Mapk6tm1Melo miceMapk6tm1Melo/Mapk6tm1Meloinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory