Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Spg11^{Gt(EUCE0085f05)Hmgu}
Name:	SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4377985
Synonyms:	Spatacsin KO

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Spastic and ataxic gait in Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mice	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6
	Severe neuron loss in the motor cortex and the cerebellum of Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mice	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6
	Accumulation of autofluoerscent material and activation of astrocytes in different regions of the central nervous system of Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mice	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6
	Purkinje cells in Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mice accumulate abnormal autolysosomes	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6
	Regeneration of lysosomes in Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} MEFs is decreased	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6
	Reduced lysosome numbers in Purkinje cells of Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mice are consistent with impaired autophagic lysosome reformation	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6
	Autolysosomes and lipofuscin-like material in different brain regions of Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mice	Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu}	involves: 129P2/OlaHsd * C57BL/6

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