Phenotype Images associated with this Allele - MGI

About Help FAQ

Phenotype Images associated with this Allele

Nomenclature

Symbol:	Acvrl1^tm2.1Spo
Name:	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
MGI ID:	MGI:4398901
Synonyms:	Alk1^1f/2f, Alk1^2loxP

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Arteriovenous malformations in the brain, lung, and GI tract of Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0	involves: 129 * FVB
	Internal bleeding and anemia, and hemorrhages in the lung and GI tract in tamoxifen treated Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ
	Wounding can induce de novo arteriovenous malformation in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ adult mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ
	Wound-induced arteriovenous malformation development in adult subdermal vessels in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ
	Blood flow through patent arteriovenous fistulas in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ
	Cerebral arteriovenous malformations in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0	involves: 129 * FVB
	Pulmonary arteriovenous malformations in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0	involves: 129 * FVB
	Enlarged heart in tamoxifen-treated Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ
	Hemorrhages and vascular malformation in the lungs and GI tract of tamoxifen-treated adult Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ mice	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ
	Uterine arteriovenous malformations in tamoxifen-treated adult Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Alk1 mutants	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129 * 129S1/Sv * 129X1/SvJ

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24