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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(Notch3*R169C)88Bbb
Name: transgene insertion 88, Norbert Hubner
MGI ID: MGI:4429538
Synonyms: TgNotch3R169C
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Tg(Notch3*R169C)88Bbb/0 mice exhibit granular osmiophilic material deposits in smooth muscle cellsTg(Notch3*R169C)88Bbb/0involves: FVB/N
White matter lesions and astrogliosis in aged Tg(Notch3*R169C)88Bbb/0 miceTg(Notch3*R169C)88Bbb/0involves: FVB/N
Arterial structure is preserved, but capillary density is progressively reduced in the white matter of Tg(Notch3*R169C)88Bbb/0 miceTg(Notch3*R169C)88Bbb/0involves: FVB/N
Vacuolization of the white matter in 20 month-old Tg(Notch3*R169C)88Bbb/0 miceTg(Notch3*R169C)88Bbb/0involves: FVB/N
20 month-old Tg(Notch3*R169C)88Bbb/0 mice exhibit white matter damage and astrogliosis in the hippocampusTg(Notch3*R169C)88Bbb/0involves: FVB/N
Progressive astrogliosis in the white matter of Tg(Notch3*R169C)88Bbb/0 mice prior to white matter disorganization and vacuolizationTg(Notch3*R169C)88Bbb/0involves: FVB/N
Tg(Notch3*R169C)88Bbb/0 mice exhibit reductions of blood flow in the brain gray and white matterTg(Notch3*R169C)88Bbb/0involves: FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory