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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ptk2tm1.1Itl
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID: MGI:4837147
Synonyms: FAKKD, FAKR454, Ptk2L454R, Ptk2tm1.1Igl
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Embryonic lethality and vascular defects in Ptk2tm1.1Itl/Ptk2tm1.1Itl embryosPtk2tm1.1Itl/Ptk2tm1.1Itlinvolves: 129S/SvEv * C57BL/6 * SJL
Defective endothelial cell patterning within Ptk2tm1.1Itl/Ptk2tm1.1Itl embryosPtk2tm1.1Itl/Ptk2tm1.1Itlinvolves: 129S/SvEv * C57BL/6 * SJL
Primary Ptk2tm1.1Itl/Ptk2tm1.1Itl MEFs exhibit increased focal adhesion formation and lack persistence of cell movementPtk2tm1.1Itl/Ptk2tm1.1Itlinvolves: 129S/SvEv * C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory