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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ptpn11tm4.2Bgn
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel
MGI ID: MGI:5004658
Synonyms: Ptpn11LS, Ptpn11Y279C
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Ptpn11tm4.2Bgn/Ptpn11+ mice demonstrate phenotypic abnormalities similar to those in human Leopard syndrome (LS)Ptpn11tm4.2Bgn/Ptpn11+involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Ptpn11tm4.2Bgn/Ptpn11+ mice have pathological cardiac hypertrophyPtpn11tm4.2Bgn/Ptpn11+involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Myofiber disarray, enlarged nuclei, and fibrosis in 52-week-old Ptpn11tm4.2Bgn/Ptpn11+ heartsPtpn11tm4.2Bgn/Ptpn11+involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Ptpn11tm4.2Bgn/Ptpn11+ mice have hypertrophic cardiomyopathy that progresses to chamber dilationPtpn11tm4.2Bgn/Ptpn11+involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory