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Phenotype Images associated with this Allele
Nomenclature
Symbol: Nbeal2tm1Lex
Name: neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID: MGI:5007262
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Lack of alpha-granules in Nbeal2tm1Lex/Nbeal2tm1Lex plateletsNbeal2tm1Lex/Nbeal2tm1Lexinvolves: 129S5/SvEvBrd * C57BL/6J
Paucity of alpha-granules but unaltered ultrastructure in Nbeal2tm1Lex/Nbeal2tm1Lex megakaryocytesNbeal2tm1Lex/Nbeal2tm1Lexinvolves: 129S5/SvEvBrd * C57BL/6J
Severely impaired adhesion and thrombus formation of Nbeal2tm1Lex/Nbeal2tm1Lex platelets under flowNbeal2tm1Lex/Nbeal2tm1Lexinvolves: 129S5/SvEvBrd * C57BL/6J
Severely impaired arterial thrombus formation and hemostasis in Nbeal2tm1Lex/Nbeal2tm1Lex miceNbeal2tm1Lex/Nbeal2tm1Lexinvolves: 129S5/SvEvBrd * C57BL/6J
Nbeal2tm1Lex/Nbeal2tm1Lex mice are protected from cerebral ischemiaNbeal2tm1Lex/Nbeal2tm1Lexinvolves: 129S5/SvEvBrd * C57BL/6J
Impaired wound healing in Nbeal2tm1Lex/Nbeal2tm1Lex miceNbeal2tm1Lex/Nbeal2tm1Lexinvolves: 129S5/SvEvBrd * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory