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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pinx1tm1.1Kplu
Name: PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu
MGI ID: MGI:5013947
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Increased telomere elongation in Pinx1tm1.1Kplu/Pinx1+ MEFs and micePinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Anaphase bridges and chromosome instability in Pinx1tm1.1Kplu/Pinx1+ MEFsPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Anaphase bridges, lagging chromosomes and chromosome instability in Pinx1tm1.1Kplu/Pinx1+ MEFsPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Aneuploidy in Pinx1tm1.1Kplu/Pinx1+ MEFsPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Chromosome instability in Pinx1tm1.1Kplu/Pinx1+ MEFsPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Telomere elongation and anaphase bridges are prevented in Pinx1tm1.1Kplu/Pinx1+ Terttm1Leah/Terttm1Leah micePinx1tm1.1Kplu/Pinx1+
Terttm1Leah/Terttm1Leah		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
Varied histopathology of Pinx1tm1.1Kplu/Pinx1+ tumorsPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Varied histopathology of Pinx1tm1.1Kplu/Pinx1+ tumorsPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Varied histopathology of mammary gland tumors in Pinx1tm1.1Kplu/Pinx1+ micePinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Varied histopathology of lung cancer in Pinx1tm1.1Kplu/Pinx1+ micePinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Lung and mammary Pinx1tm1.1Kplu/Pinx1+ cancer cells display telomere elongation, anaphase bridges and lagging chromosomesPinx1tm1.1Kplu/Pinx1+involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Pinx1tm1.1Kplu/Pinx1tm1.1Kplu mice are embryonic lethalPinx1tm1.1Kplu/Pinx1tm1.1Kpluinvolves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory