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Phenotype Images associated with this Allele
Nomenclature
Symbol: Smad2tm1.1Nomu
Name: SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura
MGI ID: MGI:5085284
Synonyms: Smad2flox
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Cerebellar ataxia in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0		involves: C57BL/6 * SJL
Cerebellar development abnormalities in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0		involves: C57BL/6 * SJL
Increased apoptotic cell death in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 cerebellaSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0		involves: C57BL/6 * SJL
Impaired cerebellar granule cell maturation and migration in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0		involves: C57BL/6 * SJL
Purkinje cell defects in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0		involves: C57BL/6 * SJL
Reduced synaptic density in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0		involves: C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory