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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(BEST1-HTRA1)#Ybf
Name: transgene insertion, Yingbin Fu
MGI ID: MGI:5285549
Synonyms: hHTRA1+
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Tg(BEST1-HTRA1)#Ybf/0 mice develop polypoidal choroidal vasculopathyTg(BEST1-HTRA1)#Ybf/0involves: C57BL/6J
Degradation of the choroidal vessels in Tg(BEST1-HTRA1)#Ybf/0 miceTg(BEST1-HTRA1)#Ybf/0involves: C57BL/6J
Elastic lamina degradation, retinal pigment epithelium atrophy, and photoreceptor degeneration in Tg(BEST1-HTRA1)#Ybf/0 miceTg(BEST1-HTRA1)#Ybf/0involves: C57BL/6J
Polypoidal choroidal vasculopathy progression and variation in Tg(BEST1-HTRA1)#Ybf/0 miceTg(BEST1-HTRA1)#Ybf/0involves: C57BL/6J
Tg(BEST1-HTRA1)#Ybf/0 mice with polypoidal choroidal vasculopathy show extensive elastic lamina degradationTg(BEST1-HTRA1)#Ybf/0involves: C57BL/6J
Similar development of polypoidal choroidal vasculopathy in Htra1tm1Ybf/Htra1tm1Ybf Tg(BEST1-HTRA1)#Ybf/0 mice as in Tg(BEST1-HTRA1)#Ybf/0 miceTg(BEST1-HTRA1)#Ybf/0involves: C57BL/6J
Htra1tm1Ybf/Htra1tm1Ybf
Tg(BEST1-HTRA1)#Ybf/0		involves: C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory