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Phenotype Images associated with this Allele
Nomenclature
Symbol: Cplane1b2b012Clo
Name: ciliogenesis and planar polarity effector 1; Bench to Bassinet Program (B2B/CVDC), mutation 012 Cecilia Lo
MGI ID: MGI:5297398
Synonyms: Heart Under Glass, Hug, Jbts17Hug, Jbtshug
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 012-029-NB has RAA, DORV, and pulmonary stenosisCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-NB has microgantnhia, micropthalmia and cleft lipCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-NB has a cleft lip and polydactylyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-NB has polydactly on all four limbsCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC imaging of mutant 012-029-NB (E16.5) reveals DORV, right aortic arch, VSD, AVSD, and stenotic pulmonary artery (PA)Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-029-NB in the coronal view reveals DORV, subaortic VSD, hypoplastic PA, common AV valve, and right aortic arch
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-012-3 (E14.5) has DORVCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-012-3 (E14.5) in the sagittal view reveals DORV and right descending aorta
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-012-3 (E14.5) in the coronal view reveals DORV, PS, VSD, and ASD
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-003-2 (E16.5) has polydactlyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-003-2 (E16.5) has a cleft palateCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-003-2 (E16.5) presents with PTACplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-003-2 (E16.5) has hypoplastic lungsCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Ultrasound imaging of mutant 012-003-2 in the sagittal view reveals single outflow tract
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Ultrasound imaging of mutant 012-003-2 in the sagittal view reveals single outflow tract regurgitation
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Ultrasound imaging of mutant 012-003-2 in the transverse view reveals atrioventricular defects
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Ultrasound imaging of mutant 012-003-2 in sagittal view reveals polydactyly
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Ultrasound imaging of mutant 012-003-2 in the sagittal view reveals cleft palate
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-013-1 (E13.5) presents with polydactylyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-013-1 (E13.5) reveals no formation of the sternumCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-013-1 (E13.5) presents with PTACplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-013-1 (E13.5) in the coronal plane shows VSD, ASD, PT, hypoplastic lung, and PTA
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-014-1 (E16.5) has a cleft lipCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-014-1 (E16.5) presents with polydactylyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-014-1 (E16.5) has an abnormal sternumCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-014-1 (E16.5) reveals right aortic arch and DORVCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-014-1 (E16.5) has a duplex left kidneyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC imaging of mutant 012-014-1 reveals DORV, right aortic arch, thin ventricles, ASD and VSDCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-014-1 (E16.5) in the coronal plane shows thin ventricles, ASD, DORV, VSD, LV, RAA, and hypoplastic PT at DA
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-LA present with a cleft lipCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-LA presents with a cleft palateCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-LA has an incomplete fusion of the sternum and a malalignment of the ribsCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-LA has polydactylyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-LA kidney is a duplex with a few small cystsCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Immunofluorescence of mutant 012-029-LA collecting ductCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Immunofluorescence of mutant 012-029-LA ureteric bud. Cilia in ureteric buds and collecting ducts are shorter than normalCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-033-2 (E15.5) has a cleft palateCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-033-2 (E15.5) in the coronal plane shows AVSD, common atria, and hypoplastic RV
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Immunofluorescence of mutant 012-033-2 (E15.5) ureteric bud with very short ciliaCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-019-2 in the coronal plane shows AVSD, RAA, and stenotic PT
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-NC presents with cleft lip and micrognathiaCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-NC has polydactylyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-029-NC has RAA and pulmonary stenosisCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-029-NC in the coronal plane shows AVSD, common atrium, hypoplastic PA, right atrial isomerism, RAA, and stenotic PT
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-033-1 (E15.5) has severe edema with harelip and cleft palateCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012-033-1 (E15.5) has DORV and pulmonary stenosisCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of mutant 012-033-1 (E15.5) in the coronal plane shows AVSD, common atria, DORV, and PT stenosis
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012A-133-NB has polydactyly on all limbs, a short snout, and micrognathiaCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012A-133-NB has a cleft lipCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012A-133-NB is diagnosed with DORV, hypoplastic PA, and biventricular hypertrophyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of 012A-133-NB in the coronal view shows DORV, AVSD, hypoplastic PA, common PA which bifurcates into L and R branches, anomolous coronary vein and biventricular hypertrophy
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012A-133-NC has polydactly on all limbs, a short snout, and micrognathiaCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012A-133-NC has a cleft palateCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Mutant 012 A-133-NC is diagnosed with DORV, hypoplastic PA, and biventriucalr hypertrophyCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
EFIC SummaryCplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Serial 2D EFIC image stack of 012A-133-NC in the coronal view exhibits DORV, AVSD, hypoplastic PA, common PA which bifurcates into L and R branches, anomolous coronary vein, biventricular hypertrophy and left atrial isomerism
Click thumbnail to play movie.		Cplane1b2b012Clo/Cplane1b2b012CloC57BL/6J-Cplane1b2b012Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory