Phenotype Images associated with this Allele

Nomenclature

Symbol:	Cxcr4^b2b220Clo
Name:	C-X-C motif chemokine receptor 4; Bench to Bassinet Program (B2B/CVDC) mutation 220, Cecilia Lo
MGI ID:	MGI:5297422
Synonyms:	Frodo

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	2D serial EFIC image stack in the coronal view reveals perimembranous VSD and overriding aorta Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Aortic arch and transverse arch hypoplasia with small left ventricle	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Narrowing of the ascending aorta	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	2D serial EFIC image stack in the transverse view reveals hypoplastic aortic arch, aortic valve atresia, and perimembranous VSD Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Duplex left kidney with hydronephrosis	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Narrowing of the aorta confirmed by EFIC imaging	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	2D serial EFIC image stack in the coronal view reveals perimembranous, muscular VSDs and double aortic arch Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	2D serial EFIC image stack in the coronal view reveals perimembranous and muscular VSDs, right aortic arch with right-sided ductus arteriosus by EFIC imaging Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Duplex left kidney with hydropnephrosis confirmed by histology	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Duplex right kidney confirmed by histology	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Hypoplastic transverse arch	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Enlarged pulmonary artery and ductus with hypoplastic transverse arch.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Tubular cysts within the kidney	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Glomerular cysts in duplex kidney with hydronephrosis	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	2D serial EFIC image stack in the transverse view reveals hypoplastic aortic arch, persistent ductus arteriosis, and hypoplastic left ventricle Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	EFIC summary	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	EFIC summary	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	EFIC summary	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	EFIC summary	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Ultrasound imaging reveals increased velocity of outflow tract blood flow	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Ultrasound imaging reveals aliasing indicative of high velocity jet in the outflow tract.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Ultrasound imaging reveals aortic stenosis with regurgitation and VSD Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Short axis view by ultrasound imaging reveals hypoplastic LV Click thumbnail to play movie.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Ultrasound imaging in the sagittal view reveals a VSD.	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	Right aortic arch	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo
	EFIC summary	Cxcr4^b2b220Clo/Cxcr4^b2b220Clo	C57BL/6J-Cxcr4^b2b220Clo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24