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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b386Clo
Name: Mutant line 386; Bench to Bassinet Program (B2B/CVDC), mutation 386 Cecilia Lo
MGI ID: MGI:5297423
Synonyms: chibi
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 386-005-1 presents with an anterior aorta which is diagnosed as DORV by EFIC imagingb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-005-1 exhibits heterotaxy including left-sided IVC, right liver isomerism (1R/1L), and left lung isomerism (2R/2L)b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
EFIC Summaryb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Serial 2D EFIC image stack in the coronal plane of 386-005-1 (E15.5) reveals DORV {A,D,D}, AVSD, and bilateral IVC
Click thumbnail to play movie.		b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Serial 2D EFIC image stack in the transverse plane of 386-005-1 reveals DORV {A,D,D}, AVSD, and bilateral IVC
Click thumbnail to play movie.		b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Ultrasound imaging of mutant 386-005-1 reveals anterior aorta and posterior pulmonary arteryb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Ultrasound imaging of mutant 386-005-1 reveals that the aorta originates from the right ventricle and a VSDb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Ultrasound imaging of mutant 386-005-1 reveals aorta originates from right ventricle with aortic regurgitation and the presence of a VSD
Click thumbnail to play movie.		b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Ultrasound imaging of mutant 386-005-1 reveals heart apex points to the left, indicative of levocardiab2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Ultrasound imaging reveals a right-sided stomach (S)b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-005-1 presents with dextrogastria and aspleniab2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-005-1 presents with left liver isomerismb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-005-2 (E15.5) exhibits heterotaxy with left lung isomerism (1R/1L) and dual IVCb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
EFIC Summaryb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Serial 2D EFIC image stack in the coronal plane of 386-005-2 (E15.5) reveals AVSD, common atrium, and bilateral IVC
Click thumbnail to play movie.		b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-005-2 (E15.5) exhibits left liver isomerism (2R/2L)b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-005-2 (E15.5) exhibits aspleniab2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Mutant 386-007-ND shows an enlarged right atrium and abnormal arrangement of the outflow tracts which is diagnosed as DORV by EFIC imagingb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
EFIC Summaryb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
Serial 2D EFIC image stack in the coronal plane of 386-007-ND reveals DORV, coronary fistula, outflow VSD, muscular VSD, ventricular myocardial non-compaction, and dilated atria/venous return
Click thumbnail to play movie.		b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.1Clo/b2b386.1CloC57BL/6J-b2b386.1Clo
EFIC Summaryb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Serial 2D EFIC image stack in the coronal plane of 386-003-ND reveals interrupted aortic arch (IAA) and spongy RV wall
Click thumbnail to play movie.		b2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Mutant 386-003-ND presents with micrognathiab2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Mutant 386-003-ND has malaligned sternal vertebrab2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Mutant 386-003-ND has a hypoplastic thymusb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Mutant 386-003-ND has duplex and hydronephrotic kidneysb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Both kidneys of mutant 386-003-ND are duplex and show hydronephrois with hydroureterb2b386Clo/b2b386CloC57BL/6J-b2b386Clo
b2b386.2Clo/b2b386.2CloC57BL/6J-b2b386.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory