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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b635Clo
Name: Mutant line 635; Bench to Bassinet Program (B2B/CVDC), mutation 635 Cecilia Lo
MGI ID: MGI:5311367
Synonyms: Ohia
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 635-004-NA exhibits hypoplastic left ventricle and ascending arch hypoplasia, which was diagnosed as HLHS by EFIC imagingb2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Mutant 635-004-NA has a hypoplastic left ventricleb2b635Clo/b2b635CloC57BL/6J-b2b635Clo
EFIC Summaryb2b635Clo/b2b635CloC57BL/6J-b2b635Clo
2D Serial EFIC image stack in the coronal view of 635-004-NA reveals hypoplastic ascending aorta, hypoplastic aortic valve, and hypoplastic left ventricle with small mitral valve
Click thumbnail to play movie.
b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
3D EFIC reconstruction of 635-004-NA showing ascending aorta hypoplasia
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b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
2D Serial EFIC image stack in the transverse view of 635-004-NA reveals hypoplastic ascending aorta, hypoplastic aortic valve, hypoplastic left ventricle with small mitral valve
Click thumbnail to play movie.
b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
2D Serial EFIC image stack in the sagittal view of 635-004-NA reveals hypoplastic ascending aorta, hypoplastic aortic valve, and hypoplastic left ventricle with small mitral valve
Click thumbnail to play movie.
b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Mutant 635-004-NG has a kinked tail and micrognathiab2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Mutant 635-004-NG presents with a hypoplastic, interrupted aortic arch and hypoplastic left ventricle which lead to the diagnosis a HLHS spectrum phenotypeb2b635Clo/b2b635CloC57BL/6J-b2b635Clo
EFIC Summaryb2b635Clo/b2b635CloC57BL/6J-b2b635Clo
2D Serial EFIC image stack in the coronal view of 635-004-NG reveals DORV, mesocardia, interrupted aortic arch, hypoplastic ascending aorta, and hypoplastic ventricle
Click thumbnail to play movie.
b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Ultrasound imaging of mutant 635-004-NG reveals hypoplastic left ventricle with reduced aortic blood flow indicating aortic hypoplasia
Click thumbnail to play movie.
b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Ultrasound imaging of mutant 635-004-NG reveals craniofacial defects (Bird face)b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Ultrasound imaging of mutant 635-004-NG reveals hypoplastic left ventricle
Click thumbnail to play movie.
b2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Ultrasound imaging of mutant 635-004-NG reveals hypoplastic left ventricleb2b635Clo/b2b635CloC57BL/6J-b2b635Clo
Mutant 635-004-NG presents with micrognathia and enophthalmia of the left eyeb2b635Clo/b2b635CloC57BL/6J-b2b635Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory