Phenotype Images associated with this Allele

Nomenclature

Symbol:	Cc2d2a^b2b1035Clo
Name:	coiled-coil and C2 domain containing 2A; Bench to Bassinet Program (B2B/CVDC), mutation 1035 Cecilia Lo
MGI ID:	MGI:5311382
Synonyms:	Blue meanie

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Heterotaxy indicated by left lung isomerism with left sided IVC and TGA (observed by EFIC imaging)	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Cystic kidneys with right kidney duplicated	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Cleft palate	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Mutant fetus at E16.5 with cleft palate	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
		Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	2D serial EFIC image stack in the coronal view reveals tricuspid atresia {ADD}, VSD, common atrium, pulmonary stenosis,and total anomalous pulmonary venous return Click thumbnail to play movie.	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	2D serial EFIC image stack in the transverse view reveals tricuspid atresia {ADD}, VSD, common atrium, and pulmonary stenosis Click thumbnail to play movie.	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Kidney displays tubular and glomerular cysts	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Cystic kidney tubules	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Proximal tubule with no cilia	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Cystic proximal tubules	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Cystic collecting ducts	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Mutant fetus (far left) has anopthalmia compared to littermate controls (2 right)	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
		Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	2D serial EFIC image stack in the coronal view reveals DORV {S(A),DD} , subpulmonary VSD, muscular VSD, AVSD, pulmonary artery stenosis and dysplastic PA valve Click thumbnail to play movie.	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Ultrasound imaging in the frontal view reveals dextrocardia and left-sided stomach Click thumbnail to play movie.	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Ultrasound imaging in 2D transverse view reveals unbalanced AVSD Click thumbnail to play movie.	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Ultrasound imaging reveals unbalanced AVSD	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Image capture showed DORV with muscular VSD	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	DORV with muscular VSD. Click thumbnail to play movie.	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo
	Image capture of color Doppler showed unbalanced AVSD with muscular VSD	Cc2d2a^b2b1035Clo/Cc2d2a^b2b1035Clo	C57BL/6J-Cc2d2a^b2b1035Clo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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