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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah5b2b1154Clo
Name: dynein, axonemal, heavy chain 5; Bench to Bassinet Program (B2B/CVDC), mutation 1154 Cecilia Lo
MGI ID: MGI:5311386
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1154-007-1 (E15.5) exhibits parallel outflow tracts which is diagnosed as DORV by EFIC imagingDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Mutant 1154-007-1 (E15.5) exhibits heterotaxy with dextrocardia, dual IVC, left lung isomerism, left liver isomerism, and dextrogastriaDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
EFIC SummaryDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
2D serial EFIC image stack in the coronal view of 1164-007-1 (E15.5) reveals dextrocardia, RAA, stenotic PA, DOmRV, AVSD, cushion-like AV valves, and right atrial isomerism
Click thumbnail to play movie.		Dnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Mutant 1154-003-LA exhibits situs inversus totalis, which is indicated by dextrocardia and dextrogastriaDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
EFIC SummaryDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
2D serial EFIC image stack in the coronal view of 1154-003-LA reveals situs mirror image dextrocardia {I,L,I}
Click thumbnail to play movie.		Dnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Mutant 1154-003-LB exhibits situs inversus totalisDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
EFIC SummaryDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
2D Serial EFIC image stack in the coronal view of 1154-003-LB reveals mirror image dextrocardia {I,L,I}, cystic lungs, and mLV hypertrophy
Click thumbnail to play movie.		Dnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Mutant 1154-003-LD exhibits heterotaxy which is indicated by levocardia, left liver isomerism, and dextrogastriaDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Mutant 1154-003-LD presents with malaligned sternal vertebraDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Mutant 1154-007-LA presents with situs inversus totalisDnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Videomicroscopy of mutant 1154-007-LA reveals immotile airway cilia
Click thumbnail to play movie.		Dnah5b2b1154Clo/Dnah5b2b1154CloC57BL/6J-Dnah5b2b1154Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory