Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Dnah11^b2b1203Clo
Name:	dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC) mutation 1203, Cecilia Lo
MGI ID:	MGI:5311388

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 1203-005-LA exhibits heterotaxy with dextrocardia, inverted lung lobation, inverted liver lobation, and left-sided stomach	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	EFIC summary	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	2D Serial EFIC image stack in the coronal plane of 1203-005-LA reveals mirror image dextrocardia {A,L,I}, RV lumen smaller than LV lumen Click thumbnail to play movie.	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Mutant 1203-005-LA shows mostly immotile tracheal airway cilia with some dyskinetic and hyperkinetic motion Click thumbnail to play movie.	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Mutant 1203-004-LA exhibits situs inversus totalis with dextrocardia, inverted lung lobation, and inverted outflow	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Mutant 1203-004-LA exhibit situs inversus totalis including dextrocardia, inverted lung lobation, inverted liver lobation, and dextrogastria	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	EFIC summary	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	2D Serial EFIC image stack in the coronal plane of 1203-004-LA reveals mirror image dextrocardia {I,L,I}, and non-compaction of ventricular myocardium Click thumbnail to play movie.	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Mutant 1203-004-LA exhibits duplex and cystic kidneys	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Mutant 1203-004-LA exhibits bilateral hydrnephrosis and likely duplex kidney	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Immunofluorescence of ureteric bud (green) show short cilia (red) in mutant 1203-004-LA	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo
	Immunofluorescence of collecting duct (green) show paucity of cilia (red) in mutant 1203-004-LA	Dnah11^b2b1203Clo/Dnah11^b2b1203Clo	C57BL/6J-Dnah11^b2b1203Clo

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