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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah11b2b1279Clo
Name: dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC) mutation 1279, Cecilia Lo
MGI ID: MGI:5311393
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1279-006-1 (E16.5) shows malalignment of the great arteries, which is diagnosed as D-TGA by EFIC imagingDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
EFIC SummaryDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
2D Serial EFIC image stack in the coronal view of 1279-006-1 (E16.5) reveals D-TGA {S,D,D}, ASD, and ventricular septal hypertrophy
Click thumbnail to play movie.		Dnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-006-1 (E16.5) presents with micrognathiaDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-006-1 (E16.5) presents with a hypoplastic thymus, left lung isomerism (1R/1L), and a left-sided IVCDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-006-2 exhibits heterotaxy with dextrocardia, inverted outflow, inverted lung lobation, normal liver lobation, and left-sided stomachDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
EFIC SummaryDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
2D Serial EFIC image stack in the coronal view of 1279-006-2 (E16.5) reveals mirror image dextrocardia, AVSD, mVSD, PA stenosis, spongy ventricles, and left lung isomerism
Click thumbnail to play movie.		Dnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-006-2 (E16.5) exhibits a hypoplastic spleenDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-006-2 exhibits malaligned sternal vertebraDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-007-LA presents with parallel outflow tracts and hypoplastic aorta which is diagnosed as DOmRV with stenotic ascending aorta by EFIC imagingDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-007-LA exhibits situs inversus totalis including dextrocardia and dextrogastria with inverted liver and lung lobationDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
EFIC SummaryDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
2D Serial EFIC image stack in the coronal view of 1279-007-LA reveals mirror image dextrocardia, DOmRV, hypoplastic mLV, mitral valve atresia, and stenotic ascending aorta
Click thumbnail to play movie.		Dnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Mutant 1279-002-LA presents with situs inversus totalis including dextrocardia and inverted lung lobationDnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Tracheal airway cilia show wide range of motion defects including immotile, slow, dyskinetic and hyperkinetic motion
Click thumbnail to play movie.		Dnah11b2b1279Clo/Dnah11b2b1279CloC57BL/6J-Dnah11b2b1279Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory