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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b251Clo
Name: Mutant line 251; Bench to Bassinet Program (B2B/CVDC), mutation 251 Cecilia Lo
MGI ID: MGI:5313696
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
2D serial EFIC images of mutant 251-005-1 (E18.5) in the coronal view reveals overriding aorta, perimembranous VSD (pmVSD), muscular VSD (mVSD), dysplastic aortic valve, and hypoplastic transvese aorta
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
2D serial EFIC images of mutant 251-007-1 (E15.5) in the coronal view reveals DORV {SDD}, non-commited VSD, muscular VSD (mVSD), dysplastic tricuspid and mitral valves, and non-compaction of ventricular myocardium
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
2D serial EFIC images of mutant 251-004-NA (newborn) in the transverse view reveals muscular VSD
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
2D serial EFIC images of mutant 251-005-1 (E18.5) in the transverse view reveals muscular and perimembranous VSDs (pmVSD).
Click thumbnail to play movie.
b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Malalignment of the great arteries suggest double outlet right ventricle (DORV) in mutant 251-007-1 (E15.5), which was subsequently confirmed by EFIC imaging.b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Transverse movie of mutant 251-004-NA obtained from micro-CT scan reveals muscular VSD (mVSD)
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Coronal movie of mutant 251-004-NA obtained from micro-CT scan reveals cystic lung
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
2D serial EFIC images of mutant 251-004-NA (newborn) in the coronal view reveals perimembranous VSD (pmVSD) and cystic lungs
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Color flow ultrasound imaging of fetus 251-005-1 (E18.5) showed aliasing in the aortic arch, indicating coarctation.
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b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Color flow ultrasound imaging of fetus 251-005-1 (E18.5) show aliasing at aortic arch, suggesting coarctation.b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Color flow Doppler imaging of fetus 251-005-1 (E18.5) in the transverse view showed VSD.
Click thumbnail to play movie.
b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
Color flow ulrasound imaging in transverse view of fetus 251-005-1 (E18.5) show presence of VSD.b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
b2b251Clo/b2b251CloC57BL/6J-b2b251Clo
b2b251Clo/b2b251CloC57BL/6J-b2b251Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory