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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pcsk5b2b585Clo
Name: proprotein convertase subtilisin/kexin type 5; Bench to Bassinet Program (B2B/CVDC), mutation 585 Cecilia Lo
MGI ID: MGI:5313702
Synonyms: McRib
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 585-004-1 shows right hindlimb syndactyly.Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Mutants show hydrops, no tail and hindlimb syndactyly.Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Kidney agenesis in mutant 585-004-1Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
2D serial EFIC image stack of mutant 585-004-1 in the coronal view reveals PTA (type I), AVSD, double aortic arch (AA), and vascular ring
Click thumbnail to play movie.		Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Mutant 585-004-1 shows kidney agenesisPcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
EFIC SummaryPcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Mutant line 585 reveals mesocardia or dextrocardia with double aortic arch (AA).Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Mutant 585-025-NA show mesocardia with hypoplastic/dysplastic kidneys, supernumerary/malformed ribs, and cleft palate.Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
2D serial EFIC image stack in the coronal view of 585-011-2 shows mesocardia with double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD)
Click thumbnail to play movie.		Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Mutant 585-025-NB show dextrocardia, dysplastic kidneys, syndactyly, malpositioned thymus, and malformed ribs.Pcsk5b2b585Clo/Pcsk5b2b585CloC57BL/6J-Pcsk5b2b585Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory