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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b508Clo
Name: Mutant line 508; Bench to Bassinet Program (B2B/CVDC), mutation 508 Cecilia Lo
MGI ID: MGI:5313714
Synonyms: Manatee
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 508-004-NL exhibits malalignment of the great arteries with blood congested atria and inferior vena cava (IVC).b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
2D serial EFIC image stack of mutant 508-004-NL in the coronal view reveals double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
2D serial EFIC image stack of mutant 508-004-NH in the coronal view reveals double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
2D serial EFIC image stack of mutant 508-004-NK in the coronal view reveals double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NL exhibits anopthalmia, microcephaly and micrognathiab2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NL exhibits micrognathia with no lower jaw and no oral opening.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH kidney show absence of cilia (611-B1, red) in the collecting duct/ureteric bud (DBA, green).b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH kidney show absence of cilia (611-B1, red) in the collecting duct/ureteric bud (DBA, green).b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH kidney show absence of cilia (611-B1, red) in the collecting duct/ureteric bud (DBA, green).b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH has abnormally shaped kidneys but no evidence of cystic disease.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
Smarca4b2b508.1Clo/Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-005-NA shows craniofacial defect with anencephaly.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
b2b508.2Clo/b2b508.2CloC57BL/6J-b2b508.2Clo
EFIC Summaryb2b508Clo/b2b508CloC57BL/6J-b2b508Clo
b2b508.2Clo/b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NE exhibit anopthalmia, microcephaly, absent mandibles, and low set pinnae.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
b2b508.2Clo/b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NE exhibit displaced pinnae and micrognathia with no mandible.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
b2b508.2Clo/b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NF exhibit anopthalmia, microcephaly, proboscis with no maxilla/mandible, and misplaced pinnae.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
b2b508.2Clo/b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NF exhibit anopthalmia, microcephaly with displaced pinnae, and micrognathia with no oral cavity.b2b508Clo/b2b508CloC57BL/6J-b2b508Clo
b2b508.2Clo/b2b508.2CloC57BL/6J-b2b508.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory