About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b508Clo
Name: Mutant line 508; Bench to Bassinet Program (B2B/CVDC), mutation 508 Cecilia Lo
MGI ID: MGI:5313714
Synonyms: Manatee
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 508-004-NL exhibits malalignment of the great arteries with blood congested atria and inferior vena cava (IVC).\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
2D serial EFIC image stack of mutant 508-004-NL in the coronal view reveals double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
2D serial EFIC image stack of mutant 508-004-NH in the coronal view reveals double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
2D serial EFIC image stack of mutant 508-004-NK in the coronal view reveals double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NL exhibits anopthalmia, microcephaly and micrognathia\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NL exhibits micrognathia with no lower jaw and no oral opening.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH kidney show absence of cilia (611-B1, red) in the collecting duct/ureteric bud (DBA, green).\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH kidney show absence of cilia (611-B1, red) in the collecting duct/ureteric bud (DBA, green).\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH kidney show absence of cilia (611-B1, red) in the collecting duct/ureteric bud (DBA, green).\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-004-NH has abnormally shaped kidneys but no evidence of cystic disease.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\Smarca4b2b508.1Clo/\Smarca4b2b508.1CloC57BL/6J-Smarca4b2b508.1Clo
Mutant 508-005-NA shows craniofacial defect with anencephaly.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\b2b508.2Clo/\b2b508.2CloC57BL/6J-b2b508.2Clo
EFIC Summary\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\b2b508.2Clo/\b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NE exhibit anopthalmia, microcephaly, absent mandibles, and low set pinnae.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\b2b508.2Clo/\b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NE exhibit displaced pinnae and micrognathia with no mandible.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\b2b508.2Clo/\b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NF exhibit anopthalmia, microcephaly, proboscis with no maxilla/mandible, and misplaced pinnae.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\b2b508.2Clo/\b2b508.2CloC57BL/6J-b2b508.2Clo
Mutant 508-004-NF exhibit anopthalmia, microcephaly with displaced pinnae, and micrognathia with no oral cavity.\b2b508Clo/\b2b508CloC57BL/6J-b2b508Clo
\b2b508.2Clo/\b2b508.2CloC57BL/6J-b2b508.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory