About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Tab1b2b449Clo
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1; Bench to Bassinet Program (B2B/CVDC), mutation 449 Cecilia Lo
MGI ID: MGI:5314079
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
2D serial EFIC image stack in the coronal view of mutant 449-005-2 (ED16.5) reveals PTA type-I
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Mutant 449-005-2 (E16.5) exhibit persistent truncus arteriosus (PTA), which was confirmed by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D serial EFIC image stack in the coronal view of mutant 449-005-1 (ED16.5) reveals DORV {SDD}, subaortic VSD, and interrupted aortic arch type-B
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Mutant 449-005-1 (E16.5) exhibit interrupted aortic arch (IAA) and malalignment of the great arteries, which was shown to be double outlet right ventricle (DORV) by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D serial EFIC image stack in the coronal plane of newborn mutant 449-002-NA reveals DORV {SDD}, suboaortic VSD, Interrupted aortic arch type-B, and high take-off right coronary artery
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Newborn mutant 449-002-NA exhibit interrupted aortic arch (IAA) and malalignment of the great arteries, confirmed as double outlet right ventricle (DORV) by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D serial EFIC image stack in the coronal plane of newborn mutant 449-003-NB (ED21.5) reveals DORV {SDD}, subaortic VSD, ASD (II), and vascular sling.
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D imaging of mutant 449-006-6 (E17.5) in transverse view showed atrioventricular septal defect (AVSD)
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in transverse view showed infow tract regurgitation at endocardial cushion level suggesting atrioventricular septal defect (AVSD).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in transverse view showed infow tract forward flow and regurgitation at endocardial cushion level suggesting atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 in transverse view showed infow tract forward flow at endocardial cushion level which indicates AVSDTab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Spectral Doppler of mutant 449-006-6 (E17.5) showed inflow tract regurgitation (R).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in sagittal view showed single outflow originating from the right ventricle (RV) with regurgitation, and a large VSD indicating persistent truncus arteriousus (PTA).
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in sagittal view showed single outflow originating from the right ventricle (RV) and a large VSD indicating persistent truncus arteriosus (PTA).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in sagittal view showed single outflow originating from the right ventricle with regurgitation, a large VSD, and persistent truncus arteriosus (PTA).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Mutant 449-006-6 (E17.5) with interrupted aortic arch (IAA) and persistent truncus arteriosus (Van Praagh type A4) confirmed by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory