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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pcsk5b2b1549Clo
Name: proprotein convertase subtilisin/kexin type 5; Bench to Bassinet Program (B2B/CVDC), mutation 1549 Cecilia Lo
MGI ID: MGI:5430343
Synonyms: Horseshoe
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1549-002-NB displays TGA (confirmed by EFIC), dual IVC and abnormal lung lobationPcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Mutant 1549-002-NB displays dual IVC and abnormal lung lobationPcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
EFIC SummaryPcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Serial 2D EFIC image stack in the coronal plane of 1549-002-NB reveals {ADD} TGA, AVSD, right aortic arch, and abnormal lung (4 lobes in right and 2 lobes in left) lobation
Click thumbnail to play movie.		Pcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
2D serial micro-MRI image stack in the coronal plane of 1549-002-NB reveals, heterotaxia, {ADD} dTGA, AVSD, bilateral IVC, right isomerism lung, and dextrogastria
Click thumbnail to play movie.		Pcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Mutant 1549-002-NB displays cleft palatePcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Mutant 1549-006-2 (E 19.5) displays malaligned sternal vertebraePcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Mesocardia with right pulmonary isomerism is shown in mutant 1549-006-2Pcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
EFIC SummaryPcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Serial 2D EFIC image stack in the coronal plane of 1549-006-2 (E19.5) reveals mesocardia, {ADD} DORV, small LV, unbalanced AVSD, and muscular VSD
Click thumbnail to play movie.		Pcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Mutant 1549-006-4 shows mesocardia with anterior positioning of the aorta and right pulmonary isomerismPcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
EFIC SummaryPcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Serial 2D EFIC image stack in the coronal plane of 1549-006-4 (E19.5) reveals {SDD} Taussig-Bing DORV, small LV, unbalanced AVSD (subpulmonary to non-commited), and right aortic arch
Click thumbnail to play movie.		Pcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Mutant 1549-006-4 (E19.5) displays patches of dyskinetic airway ciliary motion
Click thumbnail to play movie.		Pcsk5b2b1549Clo/Pcsk5b2b1549CloC57BL/6J-Pcsk5b2b1549Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory